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Ancora 1
Confirmed Speaker
  • Dr. Rossella Gottardo

CE-MS applied in forensic and clinical toxicology.

 

Rossella Gottardo

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University of Verona, Department of Diagnostics and Public Health, Section of Forensic Medicine, P.le Scuro, 10- 37134 Verona, Italy. E-mail: rossella.gottardo@univr.it

 

Capillary electrophoresis (CE) and particularly its hyphenation with mass spectrometry (CE-MS) has so far gained only moderate attention in forensic toxicology and in other forensic sciences. However, CE-MS could become an important analytical tool in the hands of forensic analysts, as it combines the high efficiency and resolution of CE with the selectivity and sensitivity of MS. Moreover, CE deals with minute amounts of sample and buffers and therefore looks more suitable than HPLC for interfacing with electrospray ionization (ESI), typically affected by ion suppression phenomena.

After several years of neglect, in recent times, the CE-MS hyphenation has recently started to be used in pharmaceutical analysis and in clinical and forensic toxicology showing great potential in qualitative and quantitative determination of therapeutic and abusive drugs and drug metabolites in body fluids and tissues.

More recently, the improvement of ion sources to meet the specificity of CE and the introduction of High Resolution Mass Spectrometry have extended the potential of CE-MS techniques, opening interesting fields of application in the forensic sciences.

These subjects will be discussed with examples of applications to real forensic cases. 

Position:

Forensic Mass Spectrometry

The aims of Forensic Mass Spectrometry Verona 2016, are to exchange scientific and technical information and to promote research, improve practice, and encourage interdisciplinary collaboration among the different areas of forensic science (forensic pathology, toxicology, genetics, criminalistics etc) based on the most advanced analytical technology.​

November 11th, 2016 - Verona, Italy

1st IMaSS Symposium on

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